Chelating Complex Micelles (CCM) are a type of polymer micelle formed at the nanoscale. Its key feature is that polymers and drugs can simultaneously "chelate" specific metal ions and form stable complex with them. Through the interaction between polymers and drugs with "chelating ligands" and metal ions, the drugs are stably encapsulated within the micelles.
Drug delivery: By chelating metal ions, the stability of the drug carrier is further enhanced. The lipid-water solubility and size of the carriers can be adjusted to modify the drug's half-life, reduce side effects, and improve the specificity and biocompatibility of therapeutic drugs.
Medical imaging, diagnosis, and treatment: If the metal ions are Gd³⁺ (MRI)、¹¹¹In (SPECT)、⁹⁹ᵐTc (SPECT)、⁶⁸Ga (PET) , imaging can be performed simultaneously to monitor the distribution of drugs within the body in real-time. In addition to diagnostic imaging, this achieves the effect of "diagnosis and therapy combined" (theranostics).
